Annu Rev Pharmacol Toxicol. Affiliated tissues include skin, liver and bone marrow. Plasmapheresis may have a role in the treatment of ED because it removes Fas-L [96], other cytokines known to be implied in the pathogenesis (IL-6, IL-8, TNF-) [97, 98]. Patient must be placed in an antidecubitus fluidized bed and room temperature must be kept at 3032C in order to slow catabolism and reduce the loss of calories through the skin [89]. Rifampin, paracetamol, metronidazole, paclitaxel, erythromycin, and ibuprofen have all been reported to cause bullous FDE. Yacoub, MR., Berti, A., Campochiaro, C. et al. The lesions consist of pruritic, annular papules, vesicles, and bullae that are found in groups, clinically it is similar to dermatitis herpetiformis, without a gluten-sensitive enteropathy [85]. Int J Mol Sci. doi: 10.4103/0019-5154.39732. Considered variables in SCORTEN are shown in Table2. Arch Dermatol. Drug-induced erythroderma invariably recovers completely with prompt initial management and removal of the offending drug. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). (PDF) DiHS/DRESS syndrome induced by second-line treatment for Journal of Pharmaceutical Research and health Care. 2008;14(12):134350. Ann Intern Med. Erythema multiforme and toxic epidermal necrolysis: a comparative study. Once ED has occurred, it has to be managed in the adequate setting with a multidisciplinary approach, and every effort has to be made to identify and avoid the trigger and to prevent infectious and non-infectious complications. To avoid the appearance of gastric stress ulcer it is recommended to start a therapy with intravenous proton pump inhibitors. 2008;58(1):3340. In spared areas it is necessary to avoid skin detachment. 2011;128(6):126676. Exfoliative Dermatitis: Symptoms, Causes, and Treatment - WebMD Kavitha Saravu. 2010;85(2):1318. Pharmacogenet Genom. TEN is characterized by full-thickness epidermal necrosis with an evident epidermal detachment and sloughing caused by necrosis of keratinocytes following apoptosis [49, 52]. N Engl J Med. For these reasons, patients should be admitted to intensive burn care units or in semi-intensive care units where they may have access to sterile rooms and to dedicated medical personnel [49, 88]. Roujeau JC, Stern RS. Growth-factors (G-CSF). Joint Bone Spine. Overall, T cells are the central player of these immune-mediated drug reactions. Nutr Clin Pract. The most notable member of this group is mycosis fungoides. 2013;27(3):35664.
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drug induced exfoliative dermatitis