Akoudad S, de Groot M, Koudstaal PJ, van der Lugt A, Niessen WJ, Hofman A, Ikram MA, Vernooij MW: Cerebral microbleeds are related to loss of white matter structural integrity. Swartz J. MRI of the Brain II. 2009, 40: 1269-1274. 2009;8:165174. Hemosiderin - Wikipedia 2007, 38: 1949-1951. Hemosiderin - an overview | ScienceDirect Topics Neurology. 2003, 9: 112-122. In long-standing cases, cerebellar atrophy may also be present. Lancet Neurol. Cerebral MBs are focal deposits of hemosiderin that indicate prior microhemorrhages around small vessels, related to either ruptured atherosclerotic microvessels or amyloid angiopathy. 2016 Dec;139(Pt 12):3151-3162. doi: 10.1093/brain/aww229. Cianchetti FA, Kim DH, Dimiduk S, Nishimura N, Schaffer CB: Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage. Neuroimaging in Superficial Siderosis: An In-Depth Look The paramagnetic properties of blood degradation products make possible the visualization of MBs in vivo, using specific magnetic resonance imaging sequences. The initial neurological examination did not reveal any definite focal pathology, but the patient appeared confused and aphasic. Seo SW, Hwa Lee B, Kim EJ, Chin J, Sun Cho Y, Yoon U, Na DL: Clinical significance of microbleeds in subcortical vascular dementia. Stroke. Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P: Prevalence and severity of microbleeds in a memory clinic setting. 2010;41:27822785. Neurology. 5. Greenberg SM, Nandigam RN, Delgado P, Betensky RA, Rosand J, Viswanathan A, Frosch MP, Smith EE: Microbleeds versus macrobleeds: evidence for distinct entities. Pathogenesis might involve direct damage to cells/tracts, but electrical disturbances associated with the leakage of blood components may have a more significant role. Google Scholar. . 2012, 79: 763-769. Four years before his hospitalisation, a man in his 90s had a left-sided intraparenchymal cerebral haemorrhage parietally with penetration into the subarachnoid space. Brain iron deposits and lifespan cognitive ability | SpringerLink 1999, 20: 637-642. Werring DJ, Sperling R: Inflammatory cerebral amyloid angiopathyand amyloid-modifying therapies: variations on the same ARIA?. Vestibulocochlear nerve (CN VIII) dysfunction resulting in a sensorineural hearing loss is believed to be due to the combination of a long cisternal course (thus with ample exposure to the subarachnoid space) and the susceptibility of microglial cells (which have a role in myelination) to be damaged by iron compounds 4.
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hemosiderin deposition in brain symptoms